Updates on mouse models of Alzheimer’s disease
Boston University · University of Massachusetts Boston · +8 more institutions
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, specifically mouse models have been developed to better elucidate disease mechanisms and test therapeutic strategies for AD. A large portion of effort in the field was focused on developing transgenic (Tg) mouse models through over-expression of genetic mutations associated with familial AD (FAD) patients. Newer generations of mouse models through knock-in (KI)/knock-out (KO) or CRISPR gene editing technologies, have been developed for both familial and sporadic AD risk genes with the hope to more accurately model proteinopathies without over-expression of human AD genes in mouse brains. In this…
Citation impact
- FWCI
- 47.43
- Percentile
- 100%
- References
- 199
Authors
5- MZMichael Z ZhongCorresponding
Boston University, University of Massachusetts Boston, Icahn School of Medicine at Mount Sinai
- TPThomas Peng
Scarsdale Public Schools, Scarsdale Historical Society, Icahn School of Medicine at Mount Sinai
- MLMariana Lemos Duarte
James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai
- MWMinghui Wang
Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai
- DCDongming Cai
University of Minnesota, Geriatric Research Education and Clinical Center, James J. Peters VA Medical Center, Minneapolis VA Health Care System, Icahn School of Medicine at Mount Sinai
Topics & keywords
- Neuroscience
- Disease
- Phenotype
- Genetically modified mouse
- Human genetics
- Model organism
- Biology
- Transgene