Platinum Nanoparticles Regulated V 2 C MXene Nanoplatforms with NIR‐II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti‐Infective Therapy

Abstract Given the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V 2 C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V 2 C MXene's laser irradiation to the near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached to V 2 C, forming artificial nanoplatforms (Pt@V 2 C). Pt@V 2 C exhibits enhanced PCE (59.6%) and a longer irradiation…

• NN
  National Natural Science Foundation of China

  Award: 22207088
• NS
  Natural Science Foundation of Zhejiang Province

  Award: LY23B010004