Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis

The severity of osteoarthritis (OA) and cartilage degeneration is highly associated with synovial inflammation. Although recent investigations have revealed a dysregulated crosstalk between fibroblast-like synoviocytes (FLSs) and macrophages in the pathogenesis of synovitis, limited knowledge is available regarding the involvement of exosomes. Here, increased exosome secretion is observed in FLSs from OA patients. Notably, internalization of inflammatory FLS-derived exosomes (inf-exo) can enhance the M1 polarization of macrophages, which further induces an OA-like phenotype in co-cultured chondrocytes. Intra-articular injection of inf-exo induces synovitis and exacerbates OA progression in murine models. In…

• NN
  National Natural Science Foundation of China

  Awards: 81991514, 82372459, 82272530, CXZX202214
• GO
  Government of Jiangsu Province
• JP
  Jiangsu Provincial Medical Youth Talent
• KT
  Key Technologies Research and Development Program

  Award: 2021YFA1201404
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 14380494, 14380493
• NM
  National Major Science and Technology Projects of China

  Award: 81991514