Implementing Whole Genome Sequencing (WGS) in Clinical Practice: Advantages, Challenges, and Future Perspectives
University of Osijek · Dartmouth–Hitchcock Medical Center · +8 more institutions
Abstract
The integration of whole genome sequencing (WGS) into all aspects of modern medicine represents the next step in the evolution of healthcare. Using this technology, scientists and physicians can observe the entire human genome comprehensively, generating a plethora of new sequencing data. Modern computational analysis entails advanced algorithms for variant detection, as well as complex models for classification. Data science and machine learning play a crucial role in the processing and interpretation of results, using enormous databases and statistics to discover new and support current genotype-phenotype correlations. In clinical practice, this technology has greatly enabled the development of personalized…
Citation impact
- FWCI
- 55.95
- Percentile
- 100%
- References
- 140
Authors
8Topics & keywords
- Pharmacogenomics
- Personalized medicine
- Genomics
- Precision medicine
- DNA sequencing
- Data science
- Whole genome sequencing
- Personal genomics