Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
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Abstract
The recent discovery of copper-mediated and mitochondrion-dependent cuproptosis has aroused strong interest in harnessing this novel mechanism of cell death for cancer therapy. Here the design of a core-shell nanoparticle, CuP/Er, for the co-delivery of copper (Cu) and erastin (Er) to cancer cells for synergistic cuproptosis and ferroptosis is reported. The anti-Warburg effect of Er sensitizes tumor cells to Cu-mediated cuproptosis, leading to irreparable mitochondrial damage by depleting glutathione and enhancing lipid peroxidation. CuP/Er induces strong immunogenic cell death, enhances antigen presentation, and upregulates programmed death-ligand 1 expression. Consequently, CuP/Er promotes proliferation and…
Citation impact
112
total citations
- FWCI
- 41.86
- Percentile
- 100%
- References
- 57
Citations per year
Authors
5Topics & keywords
Topics
Keywords
- Cancer research
- Cancer cell
- Cancer immunotherapy
- Programmed cell death
- Immunogenic cell death
- Immunotherapy
- Apoptosis
- Immune system
UN Sustainable Development Goals
- Good health and well-being
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