Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
Central South University · SKiN Health · +4 more institutions
Abstract
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate tumor suppressor mechanism and participates in the biological processes of tumors. Intriguingly, mesenchymal and dedifferentiated cancer cells, which are usually resistant to apoptosis and traditional therapies, are exquisitely vulnerable to ferroptosis, further underscoring its potential as a treatment approach for cancers, especially for refractory cancers. However, the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor cells. Ferroptosis induction not only inhibits cancer but also promotes cancer…
Citation impact
- FWCI
- 250.95
- Percentile
- 100%
- References
- 503
Authors
10- QZQian Zhou
Central South University, SKiN Health, Hunan Cancer Hospital, Xiangya Hospital Central South University
- YMYu Meng
Central South University, SKiN Health, Hunan Cancer Hospital, Xiangya Hospital Central South University
- DLDaishi Li
Central South University, SKiN Health, Hunan Cancer Hospital, Xiangya Hospital Central South University
- LYLei Yao
Central South University, Xiangya Hospital Central South University
- JLJiayuan Le
Central South University, SKiN Health, Hunan Cancer Hospital, Xiangya Hospital Central South University
Topics & keywords
- Cancer
- Cancer research
- Cancer cell
- Tumor microenvironment
- Immunotherapy
- Biology
- Immunology
- Medicine
- Good health and well-being