Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Catholic University of Korea · The Catholic University of Korea Bucheon St. Mary's Hospital
Abstract
Abstract Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through intricate response systems. Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, orchestrate the cellular hypoxic response, activating genes to increase the oxygen supply and reduce expenditure. Under conditions of excess oxygen and resulting oxidative stress, nuclear factor erythroid 2-related factor 2 (NRF2) activates hundreds of genes for oxidant removal and adaptive cell survival. Hypoxia and oxidative stress are core hallmarks of solid tumors and activated HIFs and NRF2 play pivotal roles in tumor growth and progression. The complex…
Citation impact
- FWCI
- 52.33
- Percentile
- 100%
- References
- 202
Authors
3Topics & keywords
- Oxidative stress
- Hypoxia (environmental)
- Cell biology
- Hypoxia-inducible factors
- Oxidative phosphorylation
- Tumor microenvironment
- Signal transduction
- Mitochondrion
- Affordable and clean energy