Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

Jomová, Klaudia; Alomar, Suliman Yousef; Alwasel, Saleh; Nepovimová, Eugenie; Kuča, Kamil; Valko, Marián

doi:10.1007/s00204-024-03696-4

reviewArchives of ToxicologyMar 14, 2024HYBRID OA

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

KJKlaudia Jomová SYSuliman Yousef Alomar SASaleh Alwasel ENEugenie Nepovimová KKKamil Kuča

Constantine the Philosopher University in Nitra · King Saud University · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer’s and Parkinson’s diseases), and other disorders. To counteract the harmful effects of ROS, organisms have evolved a complex, three-line antioxidant defense system. The first-line defense mechanism is the most efficient and involves antioxidant enzymes such as superoxide dismutase…

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Topics & keywords

Topics

Keywords

Antioxidant
Oxidative stress
Enzyme
Chemistry
Biochemistry

UN Sustainable Development Goals

Good health and well-being

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