Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects
Broad Institute · Foundation Center · +9 more institutions
Abstract
Summary Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide association studies that elucidate genetic etiology of complex traits. However, individuals from diverse genetic ancestry groups are often excluded from association analyses due to concerns about population structure introducing false positive associations. Here, we generate mixed model associations and meta-analyses across genetic ancestry groups, inclusive of a larger fraction of the UKB than previous efforts, to produce freely-available summary statistics for 7,266 traits. We build a quality control and analysis framework informed by genetic architecture. Overall, we identify 14,676 significant loci (p < 5 x 10 -8…
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Authors
29- KJKonrad J. KarczewskiCorresponding
Broad Institute, Foundation Center, Massachusetts General Hospital, Novo Nordisk (United States)
- RGRahul Gupta
Broad Institute, Harvard University, Massachusetts General Hospital
- MKMasahiro Kanai
Broad Institute, Harvard University, Massachusetts General Hospital
- WLWenhan Lu
Broad Institute, Massachusetts General Hospital
- KTKristin Tsuo
Broad Institute, Harvard University, Massachusetts General Hospital
Topics & keywords
- Biobank
- Genetic architecture
- Genome-wide association study
- Genetic genealogy
- Phenome
- Biology
- Genetic association
- Population