Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system

Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of ultraviolet B (UVB) requirement in the production of vitamin D3, the positive role of UVR in modulation of homeostasis is underappreciated. Skin exposure to UVR triggers local responses secondary to the induction of chemical, hormonal, immune, and neural signals that are defined by the chromophores and extent of UVR penetration into skin compartments. These responses are not random and are coordinated by the cutaneous neuro-immuno-endocrine system, which counteracts the action of external stressors and accommodates local homeostasis to the…

• UD
  U.S. Department of Defense

  Award: W81XWH2210689
• UD
  U.S. Department of Veterans Affairs

  Award: I01BX004293-01A1
• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases

  Awards: R21 AI149267-01A1, R21 MD015319
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Awards: R21AR0665051 and AR-047079, 1R01AR073004-01A1, R01AR071189-01A1, O1AR052190, 1R01AR056666