Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy
Shanghai University · Shanghai Jiao Tong University · +2 more institutions
Abstract
Abstract The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono‐immunotherapy is a new treatment modality that can reverse immunosuppressive TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia in the TME. Herein, this work reports a new sono‐immunotherapy strategy using Pd δ+ single atom catalysts to enhance positive sonodynamic responses to the immunosuppressive and sono‐suppressive TME. To demonstrate this technique, this work employs rich and reductive Ti vacancies in Ti 3‐x C 2 T y nanosheets to construct the atomically dispersed Pd‐C 3 single atom catalysts (SAC) with Pd content up to 2.5 wt% (Pd SA /Ti 3‐x C 2 T y ). Compared…
Citation impact
- FWCI
- 26.72
- Percentile
- 100%
- References
- 73
Authors
7Topics & keywords
- Materials science
- Sonodynamic therapy
- Catalysis
- Immunotherapy
- Tumor microenvironment
- Atom (system on chip)
- Nanotechnology
- Chemical engineering
- Good health and well-being