articleNature MetabolismMar 19, 2024HYBRID OA

Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

MMMathieu MembrezEMEugenia MigliavaccaSCStefan ChristenKYKeisuke YakuJTJennifer Trieu

Nestlé (Switzerland) · University of Toyama · +21 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD + ) levels are hallmarks of skeletal muscle ageing and sarcopenia 1–3 , but it is unclear whether these defects result from local changes or can be mediated by systemic or dietary cues. Here we report a functional link between circulating levels of the natural alkaloid trigonelline, which is structurally related to nicotinic acid 4 , NAD + levels and muscle health in multiple species. In humans, serum trigonelline levels are reduced with sarcopenia and correlate positively with muscle strength and mitochondrial oxidative phosphorylation in skeletal muscle. Using naturally occurring and isotopically labelled trigonelline, we…

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Topics & keywords

Topics
Keywords
  • Sarcopenia
  • Trigonelline
  • Ageing
  • NAD+ kinase
  • Function (biology)
  • Chemistry
  • Biochemistry
  • Biology
UN Sustainable Development Goals
  • Zero hunger
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