Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding

Abstract Background The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology. However, whether and how these metabolites mediate host–microbiota interactions, particularly in terms of inter-microbial communication, remains unclear. Results Here, we have demonstrated that indole-3-lactic acid (ILA) is a key molecule produced by Lactobacillus in protecting against intestinal inflammation and correcting microbial dysbiosis. Specifically, Lactobacillus metabolizes tryptophan into ILA, thereby augmenting the expression of key bacterial enzymes implicated in tryptophan metabolism, leading…

• NN
  National Natural Science Foundation of China

  Award: U180220167
• CA
  China Agricultural University
• CP
  China Postdoctoral Science Foundation

  Award: 2022M723419
• JA
  Jilin Agricultural University
• NP
  National Postdoctoral Program for Innovative Talents

  Award: BX20220342
• NK
  National Key Research and Development Program of China
• NS
  National Science Fund for Distinguished Young Scholars