Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
Union Hospital · Huazhong University of Science and Technology · +2 more institutions
Abstract
The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and extrinsic environmental factors, leads to endoplasmic reticulum stress (ER stress). As ER stress ensues, the unfolded protein response (UPR), comprising three signaling pathways-inositol-requiring enzyme 1, protein kinase R-like endoplasmic reticulum kinase, and activating transcription factor 6 promptly activates to enhance the ER's protein-folding capacity and restore ER homeostasis. However, prolonged ER stress levels propels the UPR towards cellular demise and the subsequent inflammatory cascade, contributing to the development of human diseases, including cancer, neurodegenerative…
Citation impact
- FWCI
- 31.28
- Percentile
- 100%
- References
- 137
Authors
6- SCS. C. YuanCorresponding
Union Hospital, Huazhong University of Science and Technology
- DSDan She
Union Hospital, Huazhong University of Science and Technology
- SJShangming Jiang
Union Hospital, Huazhong University of Science and Technology
- NDNan Deng
Union Hospital, Huazhong University of Science and Technology
- JPJiayi Peng
Union Hospital, Huazhong University of Science and Technology
Topics & keywords
- Endoplasmic reticulum
- Unfolded protein response
- Cell biology
- Signal transduction
- Activating transcription factor
- Biology
- Kinase
- ATF4