A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

Zepeda‐Rivera, Martha A.; Minot, Samuel S.; Bouzek, Heather; Wu, Hanrui; Blanco‐Míguez, Aitor; Manghi, Paolo; Jones, Dakota S.; LaCourse, Kaitlyn D.; Wu, Ying; McMahon, Elsa F.; Park, Soon‐Nang; Lim, Yun Kyong; Kempchinsky, Andrew G.; Willis, Amy D.; Cotton, Sean L.; Yost, Susan; Sicińska, Ewa; Kook, Joong‐Ki; Dewhirst, Floyd E.; Segata, Nicola; Bullman, Susan; Johnston, Christopher D.

doi:10.1038/s41586-024-07182-w

articleNatureMar 20, 2024HYBRID OA

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

MAMartha A. Zepeda‐Rivera SSSamuel S. Minot HBHeather Bouzek HWHanrui Wu ABAitor Blanco‐Míguez

Fred Hutch Cancer Center · University of Trento · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Fusobacterium nucleatum ( Fn ), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals 1 , is enriched in human colorectal cancer (CRC) tumours 2–5 . High intratumoural Fn loads are associated with recurrence, metastases and poorer patient prognosis 5–8 . Here, to delineate Fn genetic factors facilitating tumour colonization, we generated closed genomes for 135 Fn strains; 80 oral strains from individuals without cancer and 55 unique cancer strains cultured from tumours from 51 patients with CRC. Pangenomic analyses identified 483 CRC-enriched genetic factors. Tumour-isolated strains predominantly belong to Fn subspecies animalis ( Fna…

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Topics & keywords

Topics

Keywords

Fusobacterium nucleatum
Colorectal cancer
Biology
Cancer
Gastrointestinal tract
Fusobacterium
Microbiome
Microbiology

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