Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects in deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as a first example of a Ru(II) supramolecular ICD inducer. Ru1105 synergistically potentiates immunomodulatory responses and reduces adverse effects in deep-seated tumors through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting of tumor cells, precision organelle localization, and…

• DO
  Department of Biotechnology, Ministry of Science and Technology, India

  Award: BT/RLF/Re-entry/59/2018
• NN
  National Natural Science Foundation of China

  Awards: 22374055, 22074050, 22022404
• NR
  National Research Foundation of Korea
• NS
  Natural Science Foundation of Hubei Province

  Award: 2022CFA033
• SA
  Science and Engineering Research Board

  Award: CRG/2021/002476
• FR
  Fundamental Research Funds for the Central Universities

  Award: CCNU22QN007