reviewGut MicrobesMar 21, 2024GOLD OA

Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

RBRaquel Benedé‐UbietoFJFrancisco Javier CuberoYAYulia A. Nevzorova

Universidad Complutense de Madrid · Hospital General Universitario Gregorio Marañón · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), a growing health concern. The complex progression of MASLD extends beyond the liver, driven by "gut-liver axis," where diet, genetics, and gut-liver interactions influence disease development. The pathophysiology of MASLD involves excessive liver fat accumulation, hepatocyte dysfunction, inflammation, and fibrosis, with subsequent risk of hepatocellular carcinoma (HCC). The gut, a tripartite barrier, with mechanical, immune, and microbial components, engages in a constant communication with the liver. Recent…

Citation impact

185
total citations
FWCI
65.07
Percentile
100%
References
185
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Biology
  • Gut flora
  • Fatty liver
  • Dysbiosis
  • Liver disease
  • Insulin resistance
  • Microbiome
  • Intestinal permeability
UN Sustainable Development Goals
  • Zero hunger
No related works found for this paper.

Funding