Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy
National University of Singapore · Nanjing University of Posts and Telecommunications · +1 more institution
Abstract
Abstract Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design and precise side-chain engineering to generate •O 2 − and •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed organic PS skeletons can generate electron-hole pairs to sensitize H 2 O into •O 2 − and •OH under oxygen-free conditions with 808 nm photoexcitation, achieving NIR-photoexcited and oxygen-independent •O 2 − and •OH production. Further, compared with commonly used alkyl…
Citation impact
- FWCI
- 27.22
- Percentile
- 100%
- References
- 74
Authors
9- YTYufu TangCorresponding
National University of Singapore
- YLYuanyuan Li
Nanjing University of Posts and Telecommunications, The Synergetic Innovation Center for Advanced Materials
- BLBowen Li
National University of Singapore
- WSWentao Song
National University of Singapore
- GQGuobin Qi
National University of Singapore
Topics & keywords
- Photoexcitation
- Photodynamic therapy
- Photosensitizer
- Photochemistry
- Materials science
- Oxygen
- Chemistry
- Optoelectronics
- Good health and well-being