Activity-Based Fluorescence Diagnostics for Cancer

Fluorescence imaging is one of the most promising approaches to achieve intraoperative assessment of the tumor/normal tissue margins during cancer surgery. This is critical to improve the patients' prognosis, and therefore various molecular fluorescence imaging probes have been developed for the identification of cancer lesions during surgery. Among them, "activatable" fluorescence probes that react with cancer-specific biomarker enzymes to generate fluorescence signals have great potential for high-contrast cancer imaging due to their low background fluorescence and high signal amplification by enzymatic turnover. Over the past two decades, activatable fluorescence probes employing various fluorescence…

• JA
  Japan Agency for Medical Research and Development

  Award: JP19gm0710008
• MF
  Masason Foundation
• JS
  Japan Science and Technology Corporation

  Awards: JPMJAX222G, JPMJMI21G5
• JS
  Japan Society for the Promotion of Science

  Awards: JP19H05632, JP23K14317, JP22K20528
• MR
  Moonshot Research and Development Program

  Award: JPMJMS2022-12