Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases
Henan University of Science and Technology · Chinese Academy of Sciences · +1 more institution
Abstract
Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous and exogenous factors, the body may produce excessive ROS, which leads to oxidative stress (OS). Numerous studies have shown that OS causes a variety of pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, and protein oxidative modification, all of which can trigger apoptosis and senescence. OS also induces a variety of aging-related diseases, such as retinal disease, neurodegenerative disease, osteoarthritis, cardiovascular diseases, cancer, ovarian…
Citation impact
- FWCI
- 44.89
- Percentile
- 100%
- References
- 91
Authors
6- JYJianying Yang
Henan University of Science and Technology
- JLJuyue Luo
Henan University of Science and Technology
- XTXutong Tian
Henan University of Science and Technology
- YZYaping Zhao
Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology
- YLYumeng LiCorresponding
Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology
Topics & keywords
- Oxidative stress
- Reactive oxygen species
- Disease
- Senescence
- DNA damage
- Lipid peroxidation
- Telomere
- Antioxidant