Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
University of South Carolina · California State University, San Marcos · +1 more institution
Abstract
Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects in response to a variety of pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders and diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation of cardiovascular disorders, skin diseases, diabetes mellitus, liver and kidney injuries, and anti-tumor activities. Mechanistically, its integrative functions act through the…
Citation impact
- FWCI
- 42.21
- Percentile
- 100%
- References
- 350
Authors
5Topics & keywords
- Neuroprotection
- Inflammation
- Pharmacology
- Glucose homeostasis
- Medicine
- AMPK
- Diabetes mellitus
- Bioinformatics
- Good health and well-being
Funding
- UDU.S. Department of DefenseAwards: R01HL160541, HT9425-23-10008, R01AR073172, 1R21AR083066, R03TR004450
- NHNational Heart, Lung, and Blood InstituteAwards: R01HL160541, 1R21AR083066, HT9425-23-10008, R01AR073172, R03TR004450
- NINational Institute of Arthritis and Musculoskeletal and Skin DiseasesAwards: HT9425-23-10008, R03TR004450, R01AR073172, 1R21AR083066, R01HL160541
- NCNational Center for Advancing Translational SciencesAwards: R03TR004450, 1R21AR083066, R01AR073172, R01HL160541, HT9425-23-10008