Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears
Second Affiliated Hospital of Zhejiang University · Zhejiang University-University of Edinburgh Institute · +1 more institution
Abstract
Abstract Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration. Supramolecular interactions of β-sheets and hydrogen bonds richened by phenylboronic acid-ionic liquid (PIL) result in enhanced wet adhesion, swelling…
Citation impact
- FWCI
- 58.39
- Percentile
- 100%
- References
- 62
Authors
13- XPXihao PanCorresponding
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute, Zhejiang University
- RLRui Li
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute
- WLWenyue Li
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute, Zhejiang University
- WSWei Sun
Second Affiliated Hospital of Zhejiang University, Zhejiang University
- YYYiyang Yan
Second Affiliated Hospital of Zhejiang University, Zhejiang University-University of Edinburgh Institute, Zhejiang University
Topics & keywords
- Fibroin
- Adhesive
- Bioadhesive
- Materials science
- Tears
- Adhesion
- Genipin
- Meniscus
- Life below water