CGRP sensory neurons promote tissue healing via neutrophils and macrophages

Abstract The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective 1,2 . This is particularly relevant when immune dysregulation that results from conditions such as diabetes or advanced age impairs tissue healing following injury 2,3 . Nociceptive sensory neurons have a crucial role as immunoregulators and exert both protective and harmful effects depending on the context 4–12 . However, how neuro–immune interactions affect tissue repair and regeneration following acute injury is unclear. Here we show that ablation of the Na V 1.8 nociceptor impairs skin wound repair and muscle regeneration after acute…

• AG
  Australian Government
• SG
  State Government of Victoria
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council

  Awards: APP1176213, APP1140229
• R
  RIKEN