Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Reith, Christina; Preiss, David; Blackwell, Lisa; Emberson, Jonathan; Spata, Enti; Davies, Kelly; Halls, Heather; Harper, Charlie; Holland, Lisa; Wilson, Kate; Roddick, Alistair; Cannon, Christopher P.; Clarke, Robert; Colhoun, Helen M.; Durrington, Paul N.; Goto, Shinya; Hitman, G. A.; Hovingh, G. Kees; Jukema, J. Wouter; Köenig, Wolfgang; Marschner, Ian C.; Mihaylova, Borislava; Newman, Connie B.; Probsfield, Jeffrey L; Ridker, Paul M.; Sabatine, Marc S.; Sattar, Naveed; Schwartz, Gregory G.; Tavazzi, Luigi; Tonkin, Andrew; Trompet, Stella; White, Harvey D.; Yusuf, Salim; Armitage, Jane; Keech, Anthony; Simes, John; Collins, Rory; Baigent, Colin; Barnes, Elizabeth H; Fulcher, Jordan; Herrington, William G.; Kirby, Adrienne; O’Connell, Rachel; Amarenco, Pierre; Arashi, Hiroyuki; Barter, Philip J.; Betteridge, D. J.; Blazing, Michael A.; Blauw, Gerard J; Bosch, Jackie; Bowman, Louise; Braunwald, Eugene; Bulbulia, Richard; Byington, Robert; Clearfield, Michael; Cobbe, Stuart M.; Dahlöf, Björn; Davis, Barry R.; Lemos, James A. de; Downs, John R.; Fellström, Bengt; Flather, Marcus; Ford, Ian; Franzosi, Maria Grazia; Fuller, John A.; Furberg, Curt D.; Glynn, Robert J.; Goldbourt, Uri; Gordon, David; Gotto, Antonio M.; Grimm, Richard; Gupta, A; Hawkins, C.; Haynes, Richard; Holdaas, Hallvard; Hopewell, Jemma C.; Jardine, Alan G.; Kastelein, John J.P.; Kean, Sharon; Kearney, Patricia M.; Kitas, George D.; Kjekshus, John; Knatterud, Genell L.; Knopp, Robert H.; Koren, Michael J.; Krane, Vera; Landray, Martin; LaRosa, John C.; Latini, Roberto; Lonn, Eva; Lucci, Donata; MacFadyen, Jean; Macfarlane, Peter W.; MacMahon, Stephen; Maggioni, Aldo P.; Marchioli, Roberto; Moyé, Lemuel A.; Murphy, Sabina A.; Neil, Andrew; Nicolis, Enrico; Packard, Chris J.; Parish, Sarah; Pedersen, Terje R.; Peto, Richard; Pfeffer, Marc A.; Poulter, Neil R; Pressel, Sara; Probstfield, Jeffrey L.; Rahman, Mahboob; Robertson, Michele; Sacks, Frank M.; Schmieder, Roland E.; Serruys, Patrick W.; Sever, Peter; Shaw, John; Shepherd, James; Simpson, Lara M.; Sleight, Peter; Smeeth, Liam; Tobert, Jonathan A.; Tognoni, Gianni; Varigos, George; Wanner, Christoph; Wedel, Hans; Weis, Stephen E.; Welch, K.M.A.; Wikstrand, John; Wilhelmsen, Lars; Wiviott, Stephen D.; Yamaguchi, Junichi; Young, Robin; Zannad, Faı̈ez

doi:10.1016/s2213-8587(24)00040-8

reviewThe Lancet Diabetes & EndocrinologyMar 27, 2024HYBRID OA

Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

CRChristina Reith DPDavid Preiss LBLisa Blackwell JEJonathan Emberson ESEnti Spata

Nuffield Health · National Health and Medical Research Council

PubMed

Indexed incrossrefpubmed

Abstract

SummaryBackground Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address these gaps in knowledge through analysis of individual participant data from large, long-term, randomised, double-blind trials of statin therapy. Methods We conducted a meta-analysis of individual participant data from randomised controlled trials of statin therapy that participated in the CTT Collaboration. All double-blind randomised controlled trials of statin therapy of at least 2 years' scheduled duration and with at least 1000 participants were…

Citation impact

132

total citations

FWCI: 67.36
Percentile: 100%
References: 49

Citations per year

Authors

132

Topics & keywords

Topics

Keywords

Medicine
Statin
Diabetes mellitus
Meta-analysis
Physical therapy
Medical diagnosis
Internal medicine
Endocrinology

No related works found for this paper.