Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Matusiak, Magdalena; Hickey, John W.; IJzendoorn, David G.P. van; Lu, Guolan; Kidziński, Łukasz; Zhu, Shirley; Colburg, Deana R.C.; Luca, Bogdan; Phillips, Darci J.; Brubaker, Sky W.; Charville, Gregory W.; Shen, Jeanne; Loh, Kyle M.; Okwan‐Duodu, Derick; Nolan, Garry P.; Newman, Aaron M.; West, Robert B.; Rijn, Matt van de

doi:10.1158/2159-8290.cd-23-1300

articleCancer DiscoveryMar 27, 2024HYBRID OA

Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

MMMagdalena Matusiak JWJohn W. Hickey DGDavid G.P. van IJzendoorn GLGuolan Lu ŁKŁukasz Kidziński

Stanford University · California Institute for Regenerative Medicine · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial distribution and cell interactions that shape macrophage tissue roles remain poorly characterized. Here, we spatially resolve five distinct human macrophage populations in normal and malignant human breast and colon tissue and reveal their cellular associations. This spatial map reveals that distinct macrophage populations reside in spatially segregated micro-environmental niches with conserved cellular compositions that are repeated across healthy and diseased tissue. We show that IL4I1+ macrophages phagocytose dying cells in areas with high cell turnover and predict good outcome in colon cancer. In contrast, SPP1+ macrophages…

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127

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FWCI: 27.42
Percentile: 100%
References: 65

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Authors

18

Topics & keywords

Topics

Keywords

Macrophage
Biology
Colorectal cancer
Population
Inflammasome
Cancer
Cell
Inflammation

UN Sustainable Development Goals

Good health and well-being

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