The two sides of chromosomal instability: drivers and brakes in cancer

Hosea, Rendy; Hillary, Sharon; Naqvi, S. Hassan R.; Wu, Shourong; Kasim, Vivi

doi:10.1038/s41392-024-01767-7

reviewSignal Transduction and Targeted TherapyMar 29, 2024GOLD OA

The two sides of chromosomal instability: drivers and brakes in cancer

RHRendy Hosea SHSharon Hillary SHS. Hassan R. Naqvi SWShourong Wu VKVivi Kasim

Chongqing University · Ministry of Education · +1 more institution

PubMed

Indexed incrossrefdoajpubmed

Abstract

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes in chromosomes. CIN arises from errors in DNA replication and chromosome segregation during cell division, leading to the formation of cells with abnormal number and/or structure of chromosomes. Errors in DNA replication result from abnormal replication licensing as well as replication stress, such as double-strand breaks and stalled replication forks; meanwhile, errors in chromosome segregation stem from defects in chromosome segregation machinery, including…

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Topics & keywords

Topics

Keywords

Chromosome instability
Biology
Genome instability
Telomere
Centrosome
Chromosome segregation
Carcinogenesis
Senescence

UN Sustainable Development Goals

Good health and well-being

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