Precise Tuning of the D-Band Center of Dual-Atomic Enzymes for Catalytic Therapy

Single-atom nanozyme-based catalytic therapy is of great interest in the field of tumor catalytic therapy; however, their development suffers from the low affinity of nanozymes to the substrates (H2O2 or O2), leading to deficient catalytic activity in the tumor microenvironment. Herein, we report a new strategy for precisely tuning the d-band center of dual-atomic sites to enhance the affinity of metal atomic sites and substrates on a class of edge-rich N-doped porous carbon dual-atomic sites Fe–Mn (Fe1Mn1–NCe) for greatly boosting multiple-enzyme-like catalytic activities. The as-made Fe1Mn1–NCe achieved a much higher catalytic efficiency (Kcat/Km = 4.01 × 105 S–1·M–1) than Fe1–NCe (Kcat/Km = 2.41 × 104…

• NN
  National Natural Science Foundation of China

  Award: 52261135633
• CP
  China Postdoctoral Science Foundation

  Award: 2023M730050
• CN
  China National Petroleum Corporation

  Award: 2021DQ02-1002
• PU
  Peking University
• BM
  Beijing Municipal Natural Science Foundation

  Award: Z220020
• NK
  National Key Research and Development Program of China

  Award: 2022YFE0128500
• NS
  National Science Fund for Distinguished Young Scholars

  Award: 52025133