Biomarkers of NRF2 signalling: Current status and future challenges
University of Graz · Vienna General Hospital · +24 more institutions
Abstract
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to monitor basal and inducible NRF2 signalling is vital for mechanistic understanding in translational studies. Due to some caveats related to the direct measurement of NRF2 levels, the modulation of NRF2 activity is typically determined by measuring changes in the expression of one or more of its target genes and/or the associated protein products. However, there is a lack of consensus regarding the most relevant set of these genes/proteins that best represents NRF2…
Citation impact
- FWCI
- 26.17
- Percentile
- 100%
- References
- 75
Authors
18- CMChristina Morgenstern
University of Graz, Vienna General Hospital, Medical University of Vienna
- ILIsabel Lastres‐Becker
Biomedical Research Networking Center on Neurodegenerative Diseases, Instituto de Investigaciones Biomédicas Sols-Morreale, Hospital La Paz Institute for Health Research, Centro de Investigación Biomédica en Red, Universidad Autónoma de Madrid
- BCBirsen Can Demirdöğen
TOBB University of Economics and Technology
- VMVera Marisa Costa
Universidade do Porto
- ADAndreas Daiber
Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz, German Centre for Cardiovascular Research
Topics & keywords
- GCLC
- GCLM
- HMOX1
- Biology
- Transcription factor
- Computational biology
- KEAP1
- Signalling