articleNature CommunicationsApr 1, 2024GOLD OA

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer

HCHugo CroizerRMRana MhaidlyYKYann KiefferGGGéraldine GentricLDLounes Djerroudi

Inserm · Université Paris Sciences et Lettres · +2 more institutions

PubMed
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Abstract

Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we analyze trajectory inference, deconvolute spatial transcriptomics at single-cell level and perform functional assays to generate a high-resolution integrated map of breast cancer (BC), with a focus on inflammatory and myofibroblastic (iCAF/myCAF) FAP+ CAF clusters. We identify 10 spatially-organized FAP+ CAF-related cellular niches, called EcoCellTypes, which are differentially localized within tumors. Consistent with their spatial organization, cancer cells drive the transition of detoxification-associated iCAF (Detox-iCAF) towards…

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125
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27.03
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100%
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107
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Authors

16

Topics & keywords

Topics
Keywords
  • Breast cancer
  • Extracellular matrix
  • Ductal carcinoma
  • Cancer research
  • Tumour heterogeneity
  • Phenotype
  • Transcriptome
  • Cancer cell
UN Sustainable Development Goals
  • Good health and well-being
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