Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Air Force Medical University · Chongqing Public Health Medical Center · +21 more institutions
Abstract
Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, and immune cells, plays a crucial role in immune response modulation. Nanoparticles, engineered to reshape the TME, have shown promising results in enhancing immunotherapy by facilitating targeted delivery and immune modulation. These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, and encourage T cell infiltration. Biomimetic nanoparticles further enhance…
Citation impact
- FWCI
- 54.73
- Percentile
- 100%
- References
- 616
Authors
16- QLQiang Lü
Air Force Medical University
- DKDongquan Kou
Chongqing Public Health Medical Center
- SLShenghan Lou
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
- MAMilad Ashrafizadeh
Sun Yat-sen University, Shenzhen University, Fudan University, Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University, Shandong First Medical University
- ARAmir Reza Aref
Harvard University, Dana-Farber Cancer Institute
Topics & keywords
- Tumor microenvironment
- Immunotherapy
- Immune system
- Cancer immunotherapy
- Cancer research
- Medicine
- Nanocarriers
- Cancer cell
- Good health and well-being