Nanomedicine Remodels Tumor Microenvironment for Solid Tumor Immunotherapy
Tongji University · Shanghai Tenth People's Hospital · +3 more institutions
Abstract
Although immunotherapy is relatively effective in treating hematological malignancies, their efficacy against solid tumors is still suboptimal or even noneffective presently. Compared to hematological cancers, solid tumors exhibit strikingly different immunosuppressive microenvironment, severely deteriorating the efficacy of immunotherapy: (1) chemical features such as hypoxia and mild acidity suppress the activity of immune cells, (2) the pro-tumorigenic domestication of immune cells in the microenvironment within the solid tumors further undermines the effectiveness of immunotherapy, and (3) the dense physical barrier of solid tumor tissues prevents the effective intratumoral infiltration and contact killing…
Citation impact
- FWCI
- 18.15
- Percentile
- 100%
- References
- 107
Authors
3- YGYuedong Guo
Tongji University, Shanghai Tenth People's Hospital
- PHPing HuCorresponding
Tongji University, Chinese Academy of Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanghai Tenth People's Hospital, Shanghai Institute of Ceramics
- JSJianlin ShiCorresponding
Chinese Academy of Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanghai Institute of Ceramics
Topics & keywords
- Tumor microenvironment
- Immunotherapy
- Immune system
- Solid tumor
- Cancer research
- Nanomedicine
- Chemistry
- Cancer immunotherapy
Funding
- NNNational Natural Science Foundation of ChinaAwards: 21835007, 52072394, 22335006, 22322509
- NKNational Key Research and Development Program of ChinaAward: 2022YFB3804500
- POProgram of Shanghai Academic Research LeaderAward: 23XD1424200
- KRKey Research Program of Frontier Science, Chinese Academy of SciencesAward: ZDBS-LY-SLH029