articleBiomedicine & PharmacotherapyApr 3, 2024GOLD OA

GPX4, ferroptosis, and diseases

WZWangzheqi ZhangYLYang LiuLYLiao YanCZChenglong ZhuZZZui Zou

Second Military Medical University · Changhai Hospital

PubMed
Indexed incrossrefdoajpubmed

Abstract

GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in maintaining the redox homeostasis within the body. Ferroptosis, a form of iron-dependent non-apoptotic cell death, has gained considerable attention in recent years due to its involvement in multiple pathological processes. GPX4 is closely associated with ferroptosis and functions as the primary inhibitor of this process. Together, GPX4 and ferroptosis contribute to the pathophysiology of several diseases, including sepsis, nervous system diseases, ischemia reperfusion injury, cardiovascular diseases, and cancer. This review comprehensively…

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323
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120.28
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100%
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255
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Authors

5

Topics & keywords

Topics
Keywords
  • GPX4
  • Homeostasis
  • Programmed cell death
  • Mechanism (biology)
  • Apoptosis
  • Biology
  • Medicine
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
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