Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
Shanghai Jiao Tong University · Shanghai Sixth People's Hospital · +6 more institutions
Abstract
The gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. This highlights a synergistic interaction among gut microbiota in regulating intestinal neurotransmitter production. Administering HVA, B. longum, or R. intestinalis to mouse models with chronic unpredictable mild stress (CUMS) and corticosterone (CORT)-induced depression…
Citation impact
- FWCI
- 23.71
- Percentile
- 100%
- References
- 65
Authors
25- MZMingliang ZhaoCorresponding
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- ZRZhenxing Ren
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- AZAihua Zhao
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- YTYajun Tang
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- JKJunliang Kuang
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
Topics & keywords
- Homovanillic acid
- Gut–brain axis
- Neurotransmitter
- Biology
- Gut flora
- Dopamine
- Corticosterone
- Hippocampal formation
- Good health and well-being