articleAdvanced ScienceApr 6, 2024GOLD OA

Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy

YZYang ZhuXNXuegang NiuCDChengyu DingYLYuanxiang LinWFWenhua Fang

Fujian Medical University · First Affiliated Hospital of Fujian Medical University · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy of copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with a short blood half‐life, face challenges in transporting enough amounts of Cu ions into tumor cells. This work describes the construction of carrier‐free nanoparticles (Ce6@Cu NPs), which self‐assembled by the coordination of Cu 2+ with the sonosensitizer chlorin e6 (Ce6), facilitating sonodynamic‐triggered combination of cuproptosis and ferroptosis. Ce6@Cu NPs internalized by U87MG cells induce a sonodynamic effect and glutathione (GSH) depletion capability, promoting lipid peroxidation and…

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107
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Authors

15

Topics & keywords

Topics
Keywords
  • Sonodynamic therapy
  • Glutathione
  • Chemistry
  • Lipid peroxidation
  • In vivo
  • Biophysics
  • Cancer research
  • Cancer cell
UN Sustainable Development Goals
  • Good health and well-being
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