articleNature AgingApr 9, 2024HYBRID OA

Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

MWMeng WuWTWeicheng TangYCYing ChenLXLiru XueJDJun Dai

Ministry of Education of the People's Republic of China · National Clinical Research Center for Digestive Diseases · +11 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA sequencing and spatial transcriptomics to systematically characterize human ovarian aging. Spatiotemporal molecular signatures of the eight types of ovarian cells during aging are observed. An analysis of age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway in oocyte aging. Three granulosa cells subtypes and five theca and stromal cells subtypes, as well as their spatiotemporal transcriptomics changes during aging, are identified. FOXP1 emerges as a regulator of ovarian aging, declining with age and inhibiting…

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109
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22.87
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100%
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Authors

26

Topics & keywords

Topics
Keywords
  • Transcriptome
  • Biology
  • Ovary
  • Stromal cell
  • Regulator
  • Premature ovarian insufficiency
  • Gene silencing
  • Theca
UN Sustainable Development Goals
  • Good health and well-being
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