Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases
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Abstract
The heat shock response is an evolutionarily conserved mechanism that protects cells or organisms from the harmful effects of various stressors such as heat, chemicals toxins, UV radiation, and oxidizing agents. The heat shock response triggers the expression of a specific set of genes and proteins known as heat shock genes/proteins or molecular chaperones, including HSP100, HSP90, HSP70, HSP60, and small HSPs. Heat shock proteins (HSPs) play a crucial role in thermotolerance and aiding in protecting cells from harmful insults of stressors. HSPs are involved in essential cellular functions such as protein folding, eliminating misfolded proteins, apoptosis, and modulating cell signaling. The stress response to…
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8Topics & keywords
Keywords
- Heat shock protein
- HSP60
- Hsp70
- Biology
- Heat shock
- Cell biology
- HSPA12A
- Protein folding
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