Harnessing innate immune pathways for therapeutic advancement in cancer
Shanghai Medical College of Fudan University · Fudan University · +2 more institutions
Abstract
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various cell types, not only in innate immune cells but also in adaptive immune cells, tumor cells, and stromal cells. Agonists targeting the innate immune pathway have shown profound changes in the tumor microenvironment (TME) and improved tumor prognosis in preclinical studies. However, to date, the clinical success of drugs targeting the innate immune pathway remains limited. Interestingly, recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor progression. The uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate…
Citation impact
- FWCI
- 43.40
- Percentile
- 100%
- References
- 708
Authors
6- AHAn-Kang HuCorresponding
Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital
- LSLi Sun
Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital
- HLHao Lin
Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital
- YLYuheng Liao
Ministry of Science and Technology
- HYHui Yang
Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital
Topics & keywords
- Innate immune system
- Classical complement pathway
- Immune system
- Biology
- Tumor microenvironment
- Innate lymphoid cell
- CCL18
- Cancer
- Good health and well-being