Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion

Paradoxically, tumor development and progression can be inhibited and promoted by the immune system. After three stages of immune editing, namely, elimination, homeostasis and escape, tumor cells are no longer restricted by immune surveillance and thus develop into clinical tumors. The mechanisms of immune escape include abnormalities in antitumor-associated immune cells, selection for immune resistance to tumor cells, impaired transport of T cells, and the formation of an immunosuppressive tumor microenvironment. A population of distinct immature myeloid cells, myeloid-derived suppressor cells (MDSCs), mediate immune escape primarily by exerting immunosuppressive effects and participating in the constitution…

• NN
  National Natural Science Foundation of China

  Awards: No. 82273310, No. 82372917, 82173313, 82273310, 82372917
• HU
  Huazhong University of Science and Technology

  Award: 2023BR038
• NS
  Natural Science Foundation of Hubei Province

  Award: 2022CFA016