Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific rejuvenating mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from the plasma of young mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection of young sEVs into aged mice extends their lifespan, mitigates senescent phenotypes and ameliorates age-associated functional declines in multiple tissues. Quantitative proteomic analyses identified substantial alterations in the proteomes of aged tissues after young sEV treatment, and these changes are…

• NN
  National Natural Science Foundation of China

  Awards: 31871295, SN-ZJU-SIAS-008, CIFMS-2021-I2M-5-015, 32022015, 92268120
• ZU
  Zhejiang University

  Awards: 32022015, 31871295, CIFMS-2021-I2M-5-015, SN-ZJU-SIAS-008
• MR
  Major Research Plan
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 020814380162, 020814380146