Control of working memory by phase–amplitude coupling of human hippocampal neurons
Cedars-Sinai Medical Center · Instytut Biologii Doświadczalnej im. Marcelego Nenckiego · +7 more institutions
Abstract
Abstract Retaining information in working memory is a demanding process that relies on cognitive control to protect memoranda-specific persistent activity from interference 1,2 . However, how cognitive control regulates working memory storage is unclear. Here we show that interactions of frontal control and hippocampal persistent activity are coordinated by theta–gamma phase–amplitude coupling (TG-PAC). We recorded single neurons in the human medial temporal and frontal lobe while patients maintained multiple items in their working memory. In the hippocampus, TG-PAC was indicative of working memory load and quality. We identified cells that selectively spiked during nonlinear interactions of theta phase and…
Citation impact
- FWCI
- 39.44
- Percentile
- 100%
- References
- 93
Authors
11- JDJonathan DaumeCorresponding
Cedars-Sinai Medical Center
- JKJan Kamiński
Cedars-Sinai Medical Center, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polish Academy of Sciences
- AGAndrea Gómez Palacio Schjetnan
University Health Network, University of Toronto, Krembil Research Institute
- YSYousef Salimpour
Johns Hopkins University, Johns Hopkins Medicine
- UKUmais Khan
Cedars-Sinai Medical Center
Topics & keywords
- Working memory
- Hippocampal formation
- Hippocampus
- Neuroscience
- Cognition
- Spatial memory
- Coupling (piping)
- Psychology