reviewScienceApr 18, 2024GREEN OA

Interferon- γ and infectious diseases: Lessons and prospects

JCJean‐Laurent CasanovaJDJohn D. MacMickingCNCarl Nathan

Howard Hughes Medical Institute · Inserm · +8 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon- γ (IFN- γ ), a protein secreted by lymphocytes. Forty years ago, IFN- γ was identified as a macrophage-activating factor, and, in recent years, there has been a resurgent interest in IFN- γ biology and its role in human defense. Here we assess the current understanding of IFN- γ , revisit its designation as an “interferon,” and weigh its prospects as a therapeutic against globally…

Citation impact

132
total citations
FWCI
49.54
Percentile
100%
References
195
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Virology
  • Interferon
  • Biology
  • Medicine
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
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