Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Nievergelt, Caroline M.; Maihofer, Adam X.; Atkinson, Elizabeth G.; Chen, Chia‐Yen; Choi, Karmel W.; Coleman, Jonathan R. I.; Daskalakis, Nikolaos P.; Duncan, Laramie E.; Polimanti, Renato; Aaronson, Cindy; Amstadter, Ananda B.; Andersen, Søren Bo; Andreassen, Ole A.; Arbisi, Paul A.; Ashley‐Koch, Allison E.; Austin, S. Bryn; Avdibegović, Esmina; Babić, Dragan; Bacanu, Silviu‐Alin; Baker, Dewleen G.; Batzler, Anthony; Beckham, Jean C.; Belangero, Síntia; Benjet, Corina; Bergner, Carisa; Bierer, Linda M.; Biernacka, Joanna M.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth; Brandolino, Amber; Breen, Gerome; Bressan, Rodrigo A.; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg‐Grauholm, Jonas; Bækvad‐Hansen, Marie; Børglum, Anders D.; Børte, Sigrid; Cahn, Leah; Calabrese, Joseph R.; Caldas‐de‐Almeida, José Miguel; Chatzinakos, Chris; Cheema, Sheraz; Clouston, Sean; Colodro‐Conde, Lucía; Coombes, Brandon J.; Cruz-Fuentes, Carlos S.; Dale, Anders M.; Dalvie, Shareefa; Davis, Lea K.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Désarnaud, Frank; DiPietro, Christopher P.; Disner, Seth G.; Docherty, Anna R.; Domschke, Katharina; Dyb, Grete; Kulenović, Alma Džubur; Edenberg, Howard J.; Evans, Alexandra; Fabbri, Chiara; Fani, Negar; Farrer, Lindsay A.; Feder, Adriana; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F.; Goleva, Slavina B.; Gordon, Scott D.; Goçi, Afërdita; Grasser, Lana Ruvolo; Guindalini, Camila; Haas, Magali; Hagenaars, Saskia P.; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian; Hesselbrock, Victor; Hickie, Ian B.; Hogan, Kelleigh; Hougaard, David M.; Huang, Hailiang; Huckins, Laura M.; Hveem, Kristian; Jakovljević, Miro; Javanbakht, Arash; Jenkins, Gregory D.; Johnson, Jessica; Jones, Ian; Jovanović, Tanja; Karstoft, Karen‐Inge; Kaufman, Milissa L.; Kennedy, James L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kotov, Roman; Kranzler, Henry R.; Krebs, Kristi; Kremen, William S.; Kuan, Pei Fen; Lawford, Bruce R.; Lebois, Lauren A. M.; Lehto, Kelli; Levey, Daniel F.; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D.; Logue, Mark W.; Lori, Adriana; Lu, Yi; Luft, Benjamin J.; Lupton, Michelle K.; Luykx, Jurjen J.; Makotkine, Iouri; Maples‐Keller, Jessica L.; Marchese, Shelby; Marmar, Charles R.; Martin, Nicholas G.; Martínez-Levy, Gabriela Ariadna; McAloney, Kerrie; McFarlane, Alexander C.; McLaughlin, Katie A.; McLean, Samuel A.; Medland, Sarah E.; Mehta, Divya; Meyers, Jacquelyn L.; Michopoulos, Vasiliki; Mikita, Elizabeth A.; Milani, Lili; Milberg, William; Miller, Mark W.; Morey, Rajendra A.; Morris, C. Phillip; Mors, Ole; Mortensen, Preben Bo; Mufford, Mary S.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; Nugent, Nicole R.; O’Donnell, Meaghan; Orcutt, Holly K.; Pan, Pedro Mário; Panizzon, Matthew S.; Pathak, Gita A.; Peters, Edward; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Porjesz, Bernice; Powers, Abigail; Qin, Xuejun; Ratanatharathorn, Andrew; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy‐Byrne, Peter; Ruggiero, Kenneth J.; Rung, Ariane L.; Runz, Heiko; Rutten, Bart P. F.; Viteri, Stacey Saenz de; Salum, Giovanni Abrahão; Sampson, Laura; Sánchez, Sixto E.; Santoro, Marcos; Seah, Carina; Seedat, Soraya; Seng, Julia S.; Shabalin, Andrey A.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stensland, Synne Øien; Stevens, Jennifer S.; Sumner, Jennifer A.; Teicher, Martin H.; Thompson, Wesley K.; Tiwari, Arun K.; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; Valdimarsdóttir, Unnur; Hooff, Miranda Van; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Waszczuk, Monika A.; Weber, Heike; Wendt, Frank R.; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winsvold, Bendik S.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Xia, Yan; Xiong, Ying; Yehuda, Rachel; Young, Keith A.; Young, Ross McD.; Zai, Clement C.; Zai, Gwyneth; Zervas, Mark; Zhao, Hongyu; Zoellner, Lori A.; Zwart, John‐Anker; deRoon‐Cassini, Terri A.; Rooij, Sanne J.H. van; Heuvel, Leigh L. van den; Study, AURORA; Investigators, FinnGen; Psychiatry, HUNT All-In; Stein, Murray B.; Ressler, Kerry J.; Koenen, Karestan C.

doi:10.1038/s41588-024-01707-9

reviewNature GeneticsApr 18, 2024GOLD OA

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

CMCaroline M. Nievergelt AXAdam X. Maihofer EGElizabeth G. Atkinson CCChia‐Yen Chen KWKarmel W. Choi

University of California San Diego · VA San Diego Healthcare System · +127 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental,…

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Topics

Keywords

Genome-wide association study
Biology
Neuroscience
Genetic association
Genetics
Gene
Single-nucleotide polymorphism
Genotype

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