Engineering Large‐Scale Self‐Mineralizing Bone Organoids with Bone Matrix‐Inspired Hydroxyapatite Hybrid Bioinks

Addressing large bone defects remains a significant challenge owing to the inherent limitations in self-healing capabilities, resulting in prolonged recovery and suboptimal regeneration. Although current clinical solutions are available, they have notable shortcomings, necessitating more efficacious approaches to bone regeneration. Organoids derived from stem cells show great potential in this field; however, the development of bone organoids has been hindered by specific demands, including the need for robust mechanical support provided by scaffolds and hybrid extracellular matrices (ECM). In this context, bioprinting technologies have emerged as powerful means of replicating the complex architecture of bone…

• NN
  National Natural Science Foundation of China

  Awards: 82230071, 82172098, 82202335