The Immunology of Psoriasis—Current Concepts in Pathogenesis
University of Agriculture in Krakow · Institute of Human Genetics · +4 more institutions
Abstract
Abstract Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-remitting course. The last decades of intense research uncovered a pathological network of interactions between immune cells and other types of cells in the pathogenesis of psoriasis. Emerging evidence indicates that dendritic cells, T H 17 cells, and keratinocytes constitute a pathogenic triad in psoriasis. Dendritic cells produce TNF-α and IL-23 to promote T cell differentiation toward T H 17 cells that produce key psoriatic cytokines IL-17, IFN-γ, and IL-22. Their activity results in skin inflammation and activation and hyperproliferation of keratinocytes. In addition, other cells and signaling pathways are…
Citation impact
- FWCI
- 51.78
- Percentile
- 100%
- References
- 308
Authors
3- ISIzabela Siemińska
University of Agriculture in Krakow
- MPMonika Pieniawska
Institute of Human Genetics, Polish Academy of Sciences
- TMTomasz M. GrzywaCorresponding
Children's Hospital of Philadelphia, Medical University of Warsaw, Mossakowski Medical Research Institute, Polish Academy of Sciences, Polish Academy of Sciences
Topics & keywords
- Psoriasis
- Immunology
- Immune system
- Pathogenesis
- Cytotoxic T cell
- Inflammation
- Chemokine
- CD8
- Good health and well-being