A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing

Abstract Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis and treatment, pH variation on the wound tissue can be monitored in real time, and precise treatment can be carried out promptly to promote diabetic wound healing. In this study, a lipoic acid‐modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, and ceria oxide‐molybdenum disulfide nanoparticles with a polydopamine layer (C@M@P), along with carbon quantum dots (CDs) synthesized by a hydrothermal method, are loaded into the hydrogel, thus developing a diagnostic and therapeutic hydrogel (LAMC/CD‐C@M@P). By incorporating CDs, the hydrogel…

• NN
  National Natural Science Foundation of China

  Awards: 32201109, 32360234, 52372272
• NK
  National Key Research and Development Program of China

  Award: 2022YFB4601402
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2022B1515120052, 2021A1515110557