The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids

Holmberg, Sandra; Feeney, R; K., V.; Puértolas-Balint, Fabiola; Singh, Dhirendra Kumar; Wongkuna, Supapit; Zandbergen, Lotte; Hauner, Hans; Brandl, Beate; Nieminen, Anni I.; Skurk, Thomas; Schroeder, Bjoern O.

doi:10.1038/s41467-024-47594-w

articleNature CommunicationsApr 25, 2024GOLD OA

The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids

SHSandra Holmberg RFR Feeney VKV. K.FPFabiola Puértolas-Balint DKDhirendra Kumar Singh

Umeå University · Munich Business School · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation and ex vivo analysis of colonic mucus function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact…

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Topics

Keywords

Secretion
Mucus
Function (biology)
Short-chain fatty acid
Chemistry
Dietary fiber
Cell biology
Biochemistry

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