Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
City of Hope · Beckman Research Institute · +1 more institution
Abstract
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be differentiated into most somatic cell types. iPSCs have been widely applied to model human development and diseases, perform drug screening, and develop cell therapies. In this review, we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications. We begin by discussing the pivotal discoveries that revealed the potential of a somatic cell nucleus for reprogramming and…
Citation impact
- FWCI
- 70.28
- Percentile
- 100%
- References
- 501
Authors
3Topics & keywords
- Induced pluripotent stem cell
- Reprogramming
- Somatic cell
- Regenerative medicine
- Biology
- Drug discovery
- Computational biology
- Drug development
- Good health and well-being