Light-Triggered Nanozymes Remodel the Tumor Hypoxic and Immunosuppressive Microenvironment for Ferroptosis-Enhanced Antitumor Immunity
First Affiliated Hospital of Guangzhou Medical University · South China University of Technology · +2 more institutions
Abstract
Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed for remodeling the immunosuppressive microenvironment. The Fe-TCPP-MOFs were utilized not only as a core catalysis component against tumor destruction but also as a biocompatible delivery vector of an immunologic agonist, improving its long circulation and tumor enrichment. Concurrently, it catalyzes the decomposition of H2O2 within the tumor, yielding oxygen to augment photodynamic therapy. The induced ferroptosis, in synergy with photodynamic…
Citation impact
- FWCI
- 22.21
- Percentile
- 100%
- References
- 58
Authors
6- ZFZhijin Fan
First Affiliated Hospital of Guangzhou Medical University, South China University of Technology, Guangzhou Medical University
- SWSicheng Wu
First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- HDHuaping Deng
Xiamen University
- GLGuanlin Li
First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- LHLinghong HuangCorresponding
First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
Topics & keywords
- Tumor microenvironment
- Photodynamic therapy
- Cancer research
- Immunotherapy
- Metastasis
- Immune system
- Melanoma
- Cancer immunotherapy
- Good health and well-being