Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
National Institutes of Health · University of Cambridge · +131 more institutions
Abstract
Abstract Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals ( P < 5 × 10 −8 ) from the largest single-stage blood pressure (BP) genome-wide association study to date ( n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5–18.2 mmHg, P = 2.22 × 10 −126 ) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54–9.70; P = 4.13 × 10 −44 ) in an…
Citation impact
- FWCI
- 86.18
- Percentile
- 100%
- References
- 87
Authors
198- JMJacob M. KeatonCorresponding
National Institutes of Health, University of Cambridge, Cambridge School, National Human Genome Research Institute, Vanderbilt University Medical Center
- ZKZoha Kamali
Isfahan University of Medical Sciences, University Medical Center Groningen, University of Groningen, University of Cambridge, Cambridge School
- TXTian Xie
University Medical Center Groningen, University of Groningen, University of Cambridge, Cambridge School
- AVAhmad Vaez
Isfahan University of Medical Sciences, University Medical Center Groningen, University of Cambridge, University of Isfahan, Cambridge School
- AWAriel Williams
National Institutes of Health, National Human Genome Research Institute
Topics & keywords
- Biology
- Polygenic risk score
- Multifactorial Inheritance
- Genome-wide association study
- Quantitative trait locus
- Genetics
- Blood pressure
- Genome
- Good health and well-being
Funding
- BABrigham and Women's Hospital
- NINational Institute for Health and Care Research
- BHBritish Heart Foundation
- DODepartment of Health and Social Care
- KCKing's College London
- UOUniversity of Oxford
- ETEesti TeadusagentuurAwards: PRG1291, 2014-2020, 2014-2020.4.01.15-0012
- IUIsfahan University of Medical Sciences
- ISIsrael Science Foundation
- NINational Institutes of HealthAward: K12HD04348
- SOSchool of Medicine, Duke University
- MRMedical Research CouncilAward: HDR-23007
- NINational Institute on Aging
- NINational Institute of Neurological Disorders and Stroke