Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy
Southern Medical University · Guangdong Province Stomatological Hospital
Abstract
The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer…
Citation impact
- FWCI
- 103.13
- Percentile
- 100%
- References
- 177
Authors
5Topics & keywords
- Extracellular matrix
- Cancer immunotherapy
- Immunotherapy
- Cancer research
- Cell biology
- Chemistry
- Medicine
- Immunology
- Good health and well-being